The lab investigates the choroid plexus, the vital secretory epithelium that produces the cerebrospinal fluid bathing our central nervous system. Acting as a selective border between the blood and the brain, this tissue is a key hub for neuroinflammation. We aim to decode how the choroid plexus receives signals from the body and brain, orchestrating cellular and molecular functions affecting the central nervous system in instances of acute and chronic neuroinflammation. The lab utilizes integrative approaches, including human organoids, mouse models, sequencing, proteomics, and metabolomics to interrogate choroid plexus physiology function.