Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis

Park B*, Nicaise AM**, Tsitsipatis D*, Pirvan L, Zucha D, Munteanu A, Prasad P, De Novales MLL, Bulgaru C, Kollyfas R, Whitten J, Willis CM, Culig L, Llewllyn J, Ionescu RB, Mekdad M, Simões-Abade MBC, Krzak G, Fan J, De S, Ellis MO, Suarez Cubero M, Spathopoulou A, Peruzzotti-Jametti L, Leonardi T, Balmus G, Edenhofer F, Gorospe M, Valihrach L, Mohorianu I**, Pluchino S**, Beerman I**

Neuron, Volume 113, Issue 24, 2025

Diagram showing the progression of multiple sclerosis (MS) from healthy controls to progressive MS, highlighting cellular and molecular changes, including fibroblast and iNSC behavior, epigenetic modifications, and genetic sequencing data integration.

Publications

Selected

Diagram showing the disease in a dish model of PMS, with healthy and PMS-affected fibroblasts, neurotoxic SASP, and lipid-laden senescent cells. Multiomics profiling and covariation network analysis of HMGCR are presented, highlighting the effects of simvastatin treatment, which modulates PMS neurotoxicity by influencing cholesterol-dependent transcription, cholesterol synthesis, and HMGCR activity, leading to changes in neurotoxic SASP and neuron health.

Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis

Ionescu RB*, Nicaise AM*, Reisz JA, Williams EC, Prasad P, Willis CM, Simões-Abade MBC, Sbarro L, Dzieciatkowska M, Stephenson D, Suarez Cubero M, Rizzi S, Privan L, Peruzzotti-Jametti L, Fossati V, Edenhofer F, Leonardi T, Frezza C, Mohorianu I, D’Alessandro A, Pluchino S.

Cell Stem Cell, Volume 31, Issue 11, 2024

Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis

Simões-Abade MBC*, Patterer M*, Nicaise AM**, Pluchino S**

Front Cell Neuro, 2024

Stem cells of the aging brain

Nicaise AM, Willis CM, Crocker SJ, Pluchino S.

Front in Aging Neuro, 2020

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

Nicaise AM, Wagstaff LJ, Willis CM, Paisie C, Chandok H, Robson P, Fossatti V, Williams AC, Crocker SJ.

PNAS, 116 (18), 2019

*equal contribution

**co-corresponding

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